CAR T-cells for T-cell malignancies: challenges in distinguishing between therapeutic, normal, and neoplastic T-cells
نویسندگان
چکیده
منابع مشابه
Design and development of CAR-T cells for cancer therapy
Introduction: Today, treatment with CAR-T cells is accepted as an effective treatment for blood malignancies. CAR-T cells are autologous T cells that are engineered by gene transfer techniques to express a chimeric antigen receptor (CAR). Despite the promising results and the approval of six CAR-T cell products; these products have not yet been approved for solid tumors. In addition, the high c...
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ژورنال
عنوان ژورنال: Leukemia
سال: 2018
ISSN: 0887-6924,1476-5551
DOI: 10.1038/s41375-018-0285-8